Oxygen Free Radicals and Tissue Damage

Indomethacin-induced renal damage: role of oxygen free radicals.

Nonsteroidal anti-inflammatory drugs are used extensively in clinical medicine. In spite of their therapeutic utility, however, they are known to cause significant gastrointestinal and renal toxicities, circumstances that limit their use. The side effects produced in these organs have been attributed mainly to the inhibitory effect of these drugs on the activity of cyclooxygenase, a key enzyme ...

Protein Damage and Degradation by Oxygen Radicals

Aggregation, fragmentation, amino acid modification, and proteolytic susceptibility have been studied following exposure of 17 proteins to oxygen radicals. The hydroxyl radical (‘OH) produced covalently bound protein aggregates, but few or no fragmentation products. Extensive changes in net electrical charge (both + and -) were observed. Tryptophan was rapidly lost with ‘OH exposure, and signif...

Free radicals and tissue injury -

Biochemistry of Oxygen and Its Free Radicals

Thrombolytic treatment in acute myocardial infarction achieves coronary patency in most patients.' Mortality in groups treated early after the onset of symptoms is significantly reduced,' but left ventricular function does not always improve.5 Myocardial necrosis during the period of vessel occlusion is partly responsible for the irreversible ventricular impairment that occurs even when the ves...

Oxygen free radicals and congestive heart failure.

Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive ...